Type Of Alopecia Is The Loss Of Hair
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The most widespread form of baldness is the so-called inherited alopecia (androgenic alopecia). The majority of men and the considerable part of women have this form.
This type of alopecia is the loss of hair caused by one of the following reasons:
1. excessive content of a man’s sexual hormone dihydrotestosterone (DHT);
2. hypersensitivity of hair follicles to DHT;
3. Hyperactivity of enzyme 5-alpha- reductase, which transforms testosterone in DHT.
It is estimated that androgenic alopecia makes 95 % of all cases of men’s and women’s pelade. Men’s androgenic alopecia usually starts from the line of growth of hair and moves to the crown of the head.
In the case of women’s alopecia it is a progressing thinning of hair practically all over the head, especially around the crown.
Hippocrate noticed that eunuchs do not grow bald. Later the same fact was marked by Aristotle. Now we know that excessive content of a man’s sexual hormones in conjunction with genetic predisposition can be the reason of baldness.
Actually, it is impossible to say that sexual hormones depress or intensify growth of hair in general. The result of influence of androgenic hormones or estrogen on hair will be formed by presence of special receptor on cells of hair follicle. The receptor is something like button, and a hormone is a finger which presses this button. The result of pressing depends on mechanisms which are in a follicle.
So, estrogen stimulates growth of hair on a head and depresses growth of hair on the face and body. Androgenic hormones stimulate growth of beard and moustaches, growth of hair on some areas of a body and can depress growth of hair on a head. Certainly, not only androgen is guilty for this, but also location of follicles. If on a head there are follicles which have DHT-sensitive “buttons” of stop of a growth, there will be a hair fall in answer to excessive content of androgenic hormones. If medics transplant to a head follicles from area of moustaches or beard, your excessive content of androgenic hormones will cause growth of hair on a head. By the way, one of the methods of fight against androgenic alopecia is transplantation of DHT-activated follicles on areas of baldness.
Women suffering from androgenic alopecia, usually also have such symptoms of hyperandrogenic syndrome as hair growth on the face, and also acne and seborrhea oleosa. However, virilization occurs rarely. Men and women suffering from androgenic alopecia, almost always have normal or slightly raised level of androgenic hormones in blood. And this increase of activity of enzyme 5-alpha- reductase, or increase of sensitivity of receptors to DH? causes a hair loss.
In hair bulbs there is another enzyme, it is aromatase which transforms DH? back in testosterone and estrogens. It reduces level of DH? in hair follicles and is the antagonist of enzyme 5-alpha- reductase.
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